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-synuclein, which can be a main element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) tension, recommend that dysfunction from the intracellular proteinase programs, like ubiquitin-proteasome technique or lyso

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